Simulations in PSpice can be run in batch mode. 

Interactive Mode

In this mode PSpice is invoked from command line and the simulation circuit file is loaded. See the PSpice Reference Guide for information on the command line options.

To run a set of simulation circuit files (*.cir), the following command can be used on Windows command prompt:

<path to pspice.exe/pspice.exe /r <path to cir file>

For example:

<CDS_INST_DIR>\tools\pspice\pspice.exe /r C:/mysim/test1.cir

To set up multiple simulations, a batch file can be created with each command calling a different .cir file.